The first half deals with the downfall of the Mule, while he searches for the elusive, hidden and powerful Second Foundation, a society of mentalics. The second half skips forward a number of years to when the Foundation is once again in control, and another search for the Second Foundation begins apace.
Second Foundation possibly wins the 'Greatest number of end-plot twists' award, during the phase in which the Foundation is searching for the Second Foundation. Still, you have to appreciate the thinking Asimov must have put into it, and it's a pleasant surprise to find out who, and where, the Second Foundation really are.
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