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Erica and Dan are both at work, in an effort to quell pre wedding nerves. Erica's mother has been driving her mental with her wedding superstitions, but although Erica thinks they're silly, in the course of the day she starts to believe there may be something to them. Erica's patient Stella, a young English woman about her age, has come in with cystic fibrosis. She is on the first holiday she has ever taken without her parents, but it is ending in tragedy and she is very near death. Erica, Von and Bart try desperately to keep Stella alive long enough for her to be able to give her parents a final goodbye.
Brendan, a farmer is brought into the ED after a tractor accident resulting in multiple injuries. While treating him, Steve goes down with a mystery illness. Not much later Mike also collapses while treating Brendan. Frank realises that his team is being poisoned by this patient. While they recover, he must take over the operation on Brendan's heart. Frank has to work under Mike's guidance, both well outside their comfort zone.
Frank's niece, Amy Fielding, starts work as an ED nurse, asking Frank to keep their relationship quiet as she doesn't want any favours. Jack takes an instant liking to her and under his guidance she looks after a patient, Hannah, who has presented with only mild symptoms.
But despite the apparent simplicity of the case, Amy gets behind in her work and as a result, the patient suffers catastrophic consequences. Will Amy admit her mistake? Or let Jack continue to believe he has made an error in judgement?
Dan is visited by his brother Luke, in a vain attempt to get Dan to agree to a Bucks party. Dan, however, is firm in his resolve. Will Luke respect his brother's wishes or does the evening hold more than one surprise for the Groom?