Blood 2 starts off in the year 2028 in a dark city seemingly trapped in time. Deteriorating Brownstones reach to the sky, crumbling from the weight of time. Wires and pipes crisscross the sky, the only evidence of a futuristic setting, they hold up the city like the strings of a marionette. Caleb, Bloodâ??s ill-tempered anti-hero, has walked the Earth for nearly a hundred years, trying to discover a way to resurrect the original three Chosen: Ophelia, Gabriella, and Ishmael. United they can retake the Cabal by force and help Caleb return to his former position of power as the Cabalâ??s supreme leader, a position which he feels is rightfully his.
The Cabal, the cult dedicated to the worship of the Dark God Tchernobog (Caleb's nemesis in Blood) has changed drastically over the years. No longer content to remain a disjointed army of fanatics, they have organized a corporation to front their activities. Cabalco, as it is called, has grown to hold global interests in every major economic market. The Cabal's operations extend throughout this entire corporation, even to the point of recruiting its members from Cabalco employees. Some join willingly, some not so willingly. They are everywhere, and they consider Caleb and the other Chosen to be The Great Betrayers, those that destroyed the 16th incarnation of Tchernobog. The Cabal has dedicated itself to stopping Caleb. Gideon, the current leader of the Cabal, referred to by his followers as â??The Wordâ?? has been raised from childhood to lead, and views the conflict between himself and Caleb as being very personal.
Blood 2 begins with a scene in which the final element Caleb needs in order to bring back The Chosen is being held by the Cabal. Caleb retrieves this last object and returns to an abandoned building where he performs a dark ceremony to raise the other Chosen. The Chosen then form a shaky alliance against the Cabal, which has already dispatched a small army to deal with them. Meanwhile, something is warping the very fabric of reality, turning humanity inside out, and threatening the very world The Chosen hope to rule.