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Wikipedia (usually w/spoilers)
They are neither plants nor animals. They differ from other forms of life such as the micro-organisms and the fungi. Instead they resemble the primeval body of life and are generally known as "Mushi". Their existence and appearance are unknown to many and only a limited number of humans are aware of them. Ginko is a "Mushi-shi" who travels around to investigate and find out more about the "Mushi". In the process, he also lends a helping hand to people who face problems with supernatural occurances which may be related to the "Mushi". — ANN
The Mushi are neither plant nor animal, neither microbe nor fungus. They are more like primitive life forms. Their existence is so innocuous that we don't notice that they exist until they have manifested some mysterious phenomena. They do not exist to frighten people; they just are.
These are one-off stories about Ginko, the Mushishi, one who knows about the Mushi and who acts as a mediator between humans and Mushi. During his journey, he meets various people and Mushi. — AnimeNfo
The story features ubiquitous creatures called Mushi that often display supernatural powers. Mushi are described as beings in touch with the essence of life, far more basic and pure than the grotesque creatures we are accustomed to. Due to their ephemeral nature most humans are incapable of perceiving Mushi and are oblivious to their existence, but there are a few who possess the ability to see and interact with Mushi. The Mushi depicted in the anime look very similar to floaters.
One such person is Ginko (???, Ginko), the main character of the series. He employs himself as a Mushi master (??, mushi-shi), travelling from place to place to research Mushi and aid people suffering from problems caused by them. The series is an episodic anthology in which the only common elements among episodes are Ginko and the various types of Mushi. There is no over-arching plotline. — Wikipedia
Subtitle fix on rapidshare: mushishi_subfix_niizk_.zip
Exctract and put in your mushishi folder. Substitles will override default when loaded.
Video: 704x480 (anamorphic 853x480 16:9) H.264
Audio: Japanese 2ch Vorbis
Subtitles: English ASS, SRT