Kathy Griffin is doing comedy on Rosie O'Donnell's lesbian cruise, but as much as Griffin makes her gays laugh, she recognizes that the lesbians do not appreciate her brand of humor as much as the gay men. Determined to "crack" the lesbians' funny bone, so Griffin picks the brain of power "A"list lesbian Jackie Warner of Bravo's "Work Out" fame to understand how to make the ladies laugh. But just as Griffin prepares to leave for the cruise, she receives the devastating news that her father is in the hospital. Her dad is really sick and may not make it. Griffin must balance her work commitments against her family responsibilities and her extremely strong love for her father.