The second season revolves around Vince's proposed role in the movie adaptation of Aquaman as the eponymous hero. Ari's inability to close the contract leads to trouble, but Vince manages to convince the film's director, James Cameron, that he is right for the part. However, new problems arise when the role of the leading lady goes to Mandy Moore, Vince's ex-girlfriend, for whom he still has feelings, but who is engaged to be married.
Mandy and Vince resume their romance after Mandy's engagement shows signs of problems, but she eventually returns to her boyfriend and resigns from the Aquaman project. Initially devastated, Vince finds the will to go on with the movie in the end.
However, Ari has his own problems in the form of his boss and partner, Terrance McQuewick (Malcolm McDowell), who is trying to steal Vince away from him. Near the end of the season, their conflict reaches a head and Ari is fired from the agency. E, meanwhile, starts to date Sloan (Emmanuelle Chriqui), McQuewick's daughter.
Meanwhile, Drama continues to try to become a star, even considering getting his calves augmented. He is eventually dropped by his agent, Adam Davies, after Vince decides to stick with Ari after Ari is fired. Turtle starts a career of his own, as manager of rapper Saigon.