The film takes place in a deserted New York City, which is overrun by savage, cannibalistic humans, who have degenerated into a feral subspecies as the result of an accidental release of a genetic virus that mutates any who come into contact with it. The virus, by a mixture of chance and design, has been spread globally, resulting in the destruction of mankind, although it is not made clear if the virus has infected the entire world, or a small, localized area.
In the remains of New York is Renchard (Mark Dacascos), one of a handful of people who escaped the effects of the virus. Because of this fact, Renchard has been forced to live in a constant struggle for survival, fighting the mutants daily in order to remain alive. As time draws on, Renchard realizes that he cannot continue to fight alone forever, and decides to search New York for other survivors in the hope of building up a stronger movement to fight against the mutants and hopefully to defeat them once and for all.