Charles is worn down by his home life where he and his wife struggle to cope with the demands their daughter's illness, and his job. When he meets Lucinda on the train to work in Chicago, there is an immediate spark between them. Soon they are doing lunch; dinner and drinks follow. This leads to an adulterous rendezvous in an hotel. But no sooner have they torn each others' clothes off than their room is invaded by a thief who beats Charles and rapes Lucinda.Because of the illicit nature of their relationship, Charles is reluctant to go to the Police and soon finds himself powerless to resist the every demand of the thief.In Chicago, while traveling in a commuting train from the suburbs to downtown, the publicist Charles Schine (Clive Owen) meets the married executive Lucinda Harris (Jennifer Aniston) and starts a conversation after an incident with him. Charles is married, has a worn out marriage with his wife Deanna Schine (Melissa George) and they have been saving money for years for their diabetic daughter that needs a transplantation of kidney associated to a new expensive experimental drug. A couple of days later, Charles invites Lucinda for lunch, then for some drinks and finally they begin an affair and decide to go to a cheap hotel. The room is invaded by a thief, Laroche (Vincent Cassel), who steals the couple and rapes Lucinda. A couple of days later, Charles is blackmailed, but Lucinda is reluctant of going to the police since she does not want to lose the custody of her daughter. When Laroche menaces Charles' family, the executive tries to solve the problem and the situation gets completely out of control.