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Name:Principles of Toxicology Testing~tqw~ darksiderg

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Principles of Toxicology Testing

General Information
Type.................: Ebook
Part Size............: 6,964,101 bytes

Post Information
Posted by............: ~tqw~

Release Notes
The evolution of toxicology testing finds its impetus in the continuing growth
of the chemical and pharmaceutical industries, as well as the awareness of
public health initiatives, needs, and responses that demand faster, more
accurate, more economical methods for screening potential toxicity. Concurrent
advances in biotechnology enable viable in vitro systems to compliment
traditional animal toxicology testing methods. Today, both methods are often
employed together in toxicological analysis, derivation of toxicity mechanisms,
and pre-clinical drug development.

Principles of Toxicology Testing juxtaposes the principles of animal toxicology
testing with in vitro alternative methods to highlight the importance of each
for interpretation of the significance and relevance of the other. Divided into
three parts, the book emphasizes the universal applications of the field as a
science rather than the particular steps of laboratory technique. The first part
introduces the fundamentals of the toxicology, toxicokinetics, and human risk
assessment. The second part details toxicology testing in animals and describes
acute, subchronic, and chronic studies as well as testing for mutagenicity and
carcinogenicity. Focusing on study design and determination of classical
indicators, it covers short and long term methodologies including dermal,
ocular, and reproductive. Presenting the advantages and disadvantages of each
method, part three introduces in vitro alternative testing such as cell
cultures, cellular methods for acute systemic toxicity, as well as target organ
and local toxicity. The author also considers contemporary issues such as
chemical exposure, high throughput screening, and the efforts of US and E.U.
regulatory agencies to standardize and validate in vitro techniques.

By bringing traditional and alternative testing methods into a single volume,
Principles of Toxicology Testing challenges you to interpret the significance of
toxicology testing results and construct a logical approach toward the ultimate
purpose of testing.

Table Of Contents

Preface xix
Acknowledgments .xxi
Author xxiii
SECTION I Basic Concepts in Toxicology Testing
Chapter 1 Introduction to Principles of Toxicology 3
Chapter 2 Effects of Chemicals 11
Chapter 3 Toxicokinetics 27
Chapter 4 Risk Assessment and Regulatory Toxicology 45
Chapter 5 Descriptive Animal Toxicology Tests 57
SECTION II Toxicology Testing In Vivo
Chapter 6 Acute Toxicology Testing 73
Chapter 7 Subchronic and Chronic Toxicology Testing 89
Chapter 8 Acute Dermal and Ocular Toxicity Testing 101
Chapter 9 Toxicity Testing for Fertility and Reproduction 111
Chapter 10 Carcinogenicity and Mutagenicity Testing In Vivo 131
SECTION III Toxicology Testing In Vitro
Chapter 11 Introduction to In Vitro Toxicology Testing 147
Chapter 12 Cell Culture Methodology 151
Chapter 13 Cell Culture Methods for Acute Toxicology Testing 175
Chapter 14 Toxicokinetic Studies In Vitro 203
Chapter 15 Mutagenicity Testing In Vitro 209
Chapter 16 Reproductive and Teratogenicity Studies In Vitro 229
Chapter 17 High Throughput Screening and Microarray Analysis 237
Chapter 18 Experimental Design and Statistics 245
Chapter 19 Standardization and Validation of Alternative Methods 259'
Chapter 20 Applications of Alternative Models for Toxicology Testing 275
Index 291

Product Details

* ISBN: 0849390257
* ISBN-13: 9780849390258
* Format: Hardcover, 504pp
* Publisher: CRC Press
* Pub. Date: July 2007

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