Use Latest version Of winrar or 7-Zip
Extract .rar file ..
Xp Users - Extract to :Example C\Program Files
Vista Users -Extract to Desktop First, Then Drag and Drop the Extracted folder to where ever you prefer
Go to the Extracted folder and Double Click on the >>RE4.reg file<< Click Yes Then Ok(MUST BE DONE),Then Double Click On The >>makedesktopicon<< file
Start The game from the desktop.
Simple as that :