The story revolves around Travis Touchdown, a stereotypical otaku who lives in poverty in the fictional town of Santa Destroy, California. After winning a beam katana in an internet auction he becomes a hitman and kills another hitman, Helter Skelter, which earns him rank 11 by the UAA, the governing body of assassins. For the rest of the game the player lives Travis's life, earning money and climbing the ranks of the UAA.
Unlike Killer7, the player will control the character Travis Touchdown only. The game will have a free roaming world, allowing Travis to move around on foot or on his motorcycle—the "Schpel Tiger". Game play is open-ended, with the concession that the player must kill the top ten assassins for the storyline to progress. There will exist numerous part time job side quests to earn money and gain additional weapons. The player will also level up through experience points, but the exact details have not been revealed.
Control will be handled through the Wii Remote and Nunchuk attachment, with the Remote controlling the katana beam and the Nunchuk moving Travis. Most attacks will be performed using the "A" button, with certain other moves, including finishing strikes and sword lock breaks, being executed by following on-screen instructions. Further, since the sword runs on batteries, the player will have to shake the remote from time to time to recharge it. While the sword will not follow the exact position of the remote, it will be able to distinguish between different height levels and the angle of attacks. Successful execution of these moves will provide additional chances for attacks. Travis has also been shown demonstrating professional wrestling maneuvers to subdue opponents, including an array of suplexes, done by manipulating both the Wii Remote and Nunchuck.