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Cell Biology Thesis Extract CD40 and CD40L genes and proteins xps

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for people interesting in the CD40/CD40L system

here is the TOC:

2.1 Characteristics of the CD40 protein sequence 19
2.1.1 The human sequence 19
2.1.2 The mouse sequence 20
2.2 Regulation of CD40 expression 21
2.2.1 Organization of the CD40 gene 21
2.2.1.1 The mouse gene 21
2.2.1.2 The human gene 21
2.2.2 Transcriptional regulation of CD40 expression 22
2.2.3 Post-transcriptional regulation of CD40 expression 23
2.2.3.1 Alternative splicing of the CD40 mRNA 23
2.2.3.2 Stability of the CD40 mRNA 24
2.2.4 Post-translational regulation of CD40 expression 25
2.3 Characteristics of the CD40L protein sequence 26
2.3.1 The mouse sequence 26
2.3.2 The human sequence 27
2.4 Regulation of CD40L expression 28
2.4.1 Organization of the CD40L gene 28
2.4.2 Transcriptional regulation of CD40L expression 28
2.4.3 Post-transcriptional regulation of CD40L expression 30
2.4.4 Post-translational regulation of CD40L expression 30
2.5 Three-dimensional view of the CD40−CD40L interaction 32
2.5.1 The TNF/TNF-R superfamily 32
2.5.2 The TNF family proteins 36
2.5.3 The TNF-R family proteins 37
2.5.4 The three-dimensional structure of CD40L 39
2.5.5 Three-dimensional model of the CD40–CD40L interaction 40
2.5.5.1 A three-dimensional model for CD40 40
2.5.5.2 Residues important for the CD40–CD40L interaction 41
2.5.5.3 Construction of a CD40–CD40L interaction model 42
2.5.6 Usefulness of the three-dimensional model of the CD40–CD40L interaction 45

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