The original "Mystery in Space" series ran for 110 issues from 1951 to 1966. It featured artwork by Murphy Anderson, Gil Kane, and many others, stories by John Broome, Gardner Fox, and others.
This series was an anthology comic for many years, publishing a variety of science fiction stories, and several science-fiction based heroes. It may be best known for publishing the adventures of Adam Strange.
DC revived Mystery in Space in September 2006 as an eight issue limited series written by Jim Starlin and drawn by Shane Davis. The series featured a new Captain Comet and is described as a "detective story set in the far reaches of the DCU". The first seven issues contain a backup story starring The Weird (from the eponymous 1988 miniseries), with art by Starlin.