This is a very black comedy. A mob courier (Joe Pesci) is hired to transport the heads of 8 murder victims to a mob boss. However, the duffel bag gets mixed up with the bag of a college student (Andy Comeau) who is off on a vacation in Mexico with his girl friend (Kristy Swanson) and her parents (George Hamilton, Dyan Cannon). However, the mother is a recovering alcoholic whom everyone believes is delusional when she claims to have found heads. David Spade also appears as a classmate Pesci tracks down to find the student and leads to a cryogenic lab where they steal heads to replace the missing ones.