Robert Morgan (Vincent Price) is the last man on earth, as far as he can tell. A plague killed everyone else on the planet several years ago. He was immune to it, and can only guess why. Vampires that were formerly human attack Morgan's home every night
Morgan's days are spent shoring up his home against the vampire hordes, picking up supplies in the abandoned city, and eliminating his enemies by searching out and destroying the bloodsuckers while they sleep. He maintains mirrors and garlic strands around his house and fashions stakes on his lathe to use on the walking dead. He also conducts experiments on the bacteria that caused this plague in an effort to find a cure.