Season 2, Episode 1: Raindrops Keep Falling on My Head
Original Air Date: 25 September 2005
Meredith, shattered by revelations, is forced to work with Addison, Joe collapses at the bar, Cristina has some pretty shattering news of her own, and Alex starts working on Izzie.
Season 2, Episode 2: Enough Is Enough
Original Air Date: 2 October 2005
After a fatal car accident, a man, a woman and their son are patients in the Seattle Grace hospital. The injuries of the mother reveal a family secret. Another patient has swallowed something strange, but refuses to reveal what. On the personnel level, Meredith and Cristina try to get along with the ending of their relationships. While Meredith tries to avoid Shepherd, Cristina and Burke are involved in the same medical cases. George feels uncomfortable still working with Olivia, who wants him to forgive her. Derek also reveals why he left New York.
Season 2, Episode 3: Make Me Lose Control
Original Air Date: 9 October 2005
Meredith's mother is admitted to the hospital, revealing that the once great surgeon now has Alzheimer's disease. Menwhile, Christina faints during operation and needs immediate care. She loses her baby due to complications and becomes a patient. Burke finally finds out about her pregnancy when it's too late. Mrs Grey gives hell to George because she thinks he is her husband, but George copes with it.
Season 2, Episode 4: Deny, Deny, Deny
Original Air Date: 16 October 2005
Christina becomes a patient and Meredith deals with her mother's illness.
Season 2, Episode 5: Bring the Pain
Original Air Date: 23 October 2005
A storm rages in Seattle. Izzie is very disappointed by her date with Alex, and Meredith is upset with Derek. They both complain to George, which drives him crazy. At the hospital, Cristina has a patient that uses porn as a pain killer and Meredith takes care of an Asian girl who needs to see a Shaman before surgery. There is a power shortage and George and Alex are stuck in an elevator with a critical patient. They need to perform heart surgery, but Alex is too freaked out and so George does it.
Season 2, Episode 6: Into You Like a Train
Original Air Date: 30 October 2005
A train wreck brings multiple casualties to Seattle Grace, leaving Meredith hanging for her answer. Meanwhile, Alex finds working without his "mojo" a disheartening experience, and Yang searches high and low for a missing appendage.
Season 2, Episode 7: Something to Talk About
Original Air Date: 6 November 2005
Addison and Derek go to marriage counseling. Derek says that he's finished with Meredith. Meanwhile, Meredith becomes the main gossip topic in the hospital and Izzie and Christina discover a pregnant man. Preston tells the Chief about him and Christina and Alex finally kisses Izzie.
Season 2, Episode 8: Let It Be
Original Air Date: 13 November 2005
Freinds of Derek and Addison come from New York, because the woman wants a preventative hysterectomy and mastectomy because she is afraid of cancer. Meanwhile, George is freaking out because he almost got hit by a man falling from a roof.
Season 2, Episode 9: Thanks for the Memories
Original Air Date: 20 November 2005
Thanksgiving sends the occupants of the house in different directions: Meredith escapes to the hospital, George goes hunting with his family, and Izzie throws a dinner that it appears no one is coming to.
Season 2, Episode 10: Much Too Much
Original Air Date: 27 November 2005
Meredith's one night stand causes complications when he shows up at the hospital with an embarrassing problem, Burke tries to push Cristina toward the next step, and Alex's problems affect his performance.
Season 2, Episode 11: Owner of a Lonely Heart
Original Air Date: 4 December 2005
The mother of the quints blames herself, Izzy becomes attached to her patient, Karev must face the consequences of his actions, and Cristina cares for an inmate desperate to stay at the hospital.
Season 2, Episode 12: Grandma Got Run Over by a Reindeer
Original Air Date: 11 December 2005
Christmas brings a range of holiday spirits, from über-cheer to Scrooge, and holiday maladies.
Season 2, Episode 13: Begin the Begin
Original Air Date: 15 January 2006
Izzie realizes that she is attracted to her patient with a heart condition. George treats Bex, a hermaphrodite. Meredith's mother gets a special visitors. Derek and Addison's relationship is still rocky.
Season 2, Episode 14: Tell Me Sweet Little Lies
Original Air Date: 22 January 2006
Meredith has to choose between her dog and her roommates, Alex gets his board results, and Bailey's pregnancy may be at risk.
Season 2, Episode 15: Break on Through
Original Air Date: 29 January 2006
The nurses strike, leaving the doctors unprepared for their extra duties. Cristina and Burke have to define their work relationship, Izzie relates to a pregnant teenager, and Meredith finds parallels to her mother in a case requiring her to remove life support.
Season 2, Episode 16: It's the End of the World
Original Air Date: 5 February 2006
The lives of everyone in the OR are threatened when a patient enters with a bomb inside of him... and a young paramedic with her arm inside the cavity is the only thing keeping it from going off.
Season 2, Episode 17: As We Know It
Original Air Date: 12 February 2006
While the man with the bomb lodged in his chest remains in Burke's OR, Bailey's injured husband remains in Derek's. Meanwhile, Bailey still hasn't delivered her baby.
Season 2, Episode 18: Yesterday
Original Air Date: 19 February 2006
Derek and Addison are shaken by the arrival of someone from their past. Meanwhile, Burke learns Cristina's secret, and Meredith delves into her family's dirty laundry.
Season 2, Episode 19: What Have I Done to Deserve This?
Original Air Date: 26 February 2006
Karma figures large in the minds of most of the staff for various reasons, and Meredith and George face the repercussions of their actions.
Season 2, Episode 20: Band-Aid Covers the Bullet Hole
Original Air Date: 12 March 2006
Cristina babysits for Bailey and doesn't take to it well at all. Meanwhile, Addison and Derek come to terms with their relationship, and Denny keeps coming between Alex and Izzie.
Season 2, Episode 21: Superstition
Original Air Date: 19 March 2006
A complication from the LVAD surgery puts Denny in the OR during a death cycle, Cristina maneuvers to get George kicked out, and an old mentor of the Chief's is admitted for treatment.
Season 2, Episode 22: The Name of the Game
Original Air Date: 2 April 2006
George begins to overstay his welcome at Burke and Cristina's apartment. Cristina takes a seminar and discovers that Chief Webber is taking it too. Meanwhile, Meredith learns a startling secret about her father, Bailey worries her colleagues will not treat her the same now that she's a mother, and Alex gets a lesson in bedside manners.
Season 2, Episode 23: Blues for Sister Someone
Original Air Date: 30 April 2006
While Izzie grills George about the personal details of his life, Addison takes Alex to task about a sensitive case. Also, Burke feels the pressure when he treats his musical hero, and Meredith considers dating a hunky vet.
Season 2, Episode 24: Damage Case
Original Air Date: 7 May 2006
The interns care for a family involved in a car accident. Derek lets his emotions get the better of him.
Season 2, Episode 25: 17 Seconds
Original Air Date: 14 May 2006
Burke and Izzie continue to search for a new heart. The residents treat victims of a workplace shooting.
Season 2, Episode 26: Deterioration of the Fight or Flight Response
Original Air Date: 15 May 2006
The struggle to get Denny a heart continues. Christina gets to run her own trauma. Shepherd is responsible for a friend's life. The Chief's niece is brought to the ER by his wife.
Season 2, Episode 27: Losing My Religion
Original Air Date: 15 May 2006
The chief tries to determine who's responsible. Callie presses George about his feelings. Derek and Meredith have to make a decision about Doc. The interns are charged with pleasing the chief's niece.