In a near future, the Motor City known as Detroit slowly becomes the spawn-ground for Crime as a gang of Cop Killers goes on the rise. Private organism, Omni Consomer Products (OCP) eventually seizes control of local law enforcement to ensure a secure an Urban pacification program. Just assigned to the Metro West Precint, Officer Alex Murphy is massacred to death by this gang, as his partner Anne Lewis is barely able to do nothing. At the same time, a young visionary executive, Bob Morton, seizes the chance when the ED-209 law enforcement Droid shows lack of perfection by killing a fellow executive to create the Perfect Cop. The near death Murphy is used as the subject. With his memories erased, he is resurrected as Robocop, the future of law enforcement. As he sweeps away with crime, case by case, he eventually becomes involved with the Cop Killing Gang, and Anne Lewis herself. All of this, triggering his dormant memories of his past life as he searches for who he really is, and uncover a conspiracy going deep in OCP with the Senior Vice President himself.
After a successful deployment of the Robocop Law Enforcement unit, OCP sees its goal of urban pacification closer and closer. But as this develops, a new narcotic known as "Nuke" invades the streets, leaded by God-delirious leader Kane. As this whole menace grows, it may even prove to be too much for Murphy to handle. OCP tries to replicate the success of the first unit, but ends up in failed prototypes with suicidal issues... until Dr. Faxx, scientist straying away from OCP's path uses Kane as the new subject for the Robocop 2 project, a living God.
Omni Consumer Products (OCP) begins its plan for the creation of Delta City. As part of this program, a special Rehab squad leaded by Commander Paul McDaggett is deployed as they evacuate the city in a forced manner tearing down part of the city. In this chaos, a young girl named Nikko is left alone and picked up by a group of citizens joining together to strike on OCP, first raiding a Police Department Armory Warehouse. Murphy is sent to the chase of this group, but he eventually ignored the order when he received a back up call from Anne Lewis and the other officers who were attacked by a group of Cyber Punks. This violation leads to the decision of finally cutting Murphy's past memories for good, as he finds himself between the line of Law Enforcement and Popular Opinion when the law is beginning to be corrupted, and he is betrayed by the law he sought to uphold when Lewis is killed, and he is left for dead... all of this thanks to Directive 4: "Any attempt to arrest an officer of OCP results in Shut Down." At the same time, the new younger CEO of OCP begins relations with a Japanese Cybernetics Corporation leaded by a man named Kanemitsu for Monetary support, leading into the deployment of the advanced Android Otomo, a fully skilled Ninja with full human appearance, but still a machine. Slowly as all of Detroit joins the Motor City's cause, including the Police Department, McDaggett sees use for the arrested criminals to create his own army of criminals to strike down the City's militia once and for all. The only hope, Murphy overcoming the control placed on him by Directive 4, and bring down this corrupted plan.