On a warm September evening, college professor Ethan Learner, his wife Grace, and their daughter Emma are attending a recital. Their 10-year-old son Josh is playing cello -- beautifully, as usual. His younger sister looks up to him, and his parents are proud of their son. On the way home, they all stop at a gas station on Reservation Road. There, in one terrible instant, he is taken from them forever. On a warm September evening, law associate Dwight Arno and his 11-year-old son Lucas are attending a baseball game. Their favorite team, the Red Sox, is playing - and, hopefully, heading for the World Series. Dwight cherishes his time spent with Lucas. Driving his son back to his ex-wife, Lucas' mother Ruth Wheldon, Dwight heads towards his fateful encounter at Reservation Road.
Het verhaal over Ethan Learner en Dwight Arno, twee vaders die aan het hoofd staan van families die met elkaar verbonden zijn door het tragische sterfgeval van de zoon van één van hen. De verwerking door beide families verloopt niet bepaald soepel en brengt allerlei emotionele confrontaties met zich mee.