The Denver Ghostbusters have returned. More than two years have passed since the events depicted in Freddy VS Ghostbusters. Business is booming, and the 'busters are becoming town celebrities. Leaps in new ghostbusting technology promises to bring more efficiency to the hunt, as branches of the franchise have popped up around the globe.
Recently, the famous archaeologist Dr. Klaus Constantin has discovered an artifact of great power in outside the ancient Egyptian city of Cynopolis. This artifact, known as the Amulet of Anubis is fabled to carry with it the very powers of Anubis himself--the most ancient guardian of the underworld. Constantin brings the talisman to Denver, where he hopes to use it to open a portal to the other side. Honestly, what harm has opening a portal to another dimension ever caused? The mile high city is rocked when the paranormal eliminators face off against the forces of darkness in a battle for Earth's souls.