* Zeenat Aman as Roma
* Pran as Jasjit (J.J.)
* Iftekhar as DSP D'Silva (credited as Iftikhar)
* Om Shivpuri as Interpol Officer R.K. Malik
* Satyen Kappu as Inspector S. Verma (credited as Satyen Kapoo)
* P. Jairaj as Dayal (Judo Karate Instructor)
* Kamal Kapoor as Narang
* Arpana Choudhary as Anita (credited as Arpana Choudhry)
* Helen as Kamini
* M.B. Shetty as Shakaal (credited as Shetty)
* Mac Mohan as Mac
* Azad as Azad
* Don was first remade in 1979 in Telugu as Yugandhar, starring N.T. Rama Rao and Jayasudha. In 2008, negotiations began to remake Yugandhar.
* Another remake was made in Tamil titled Billa (1980), starring Rajnikanth. The film was then remade in Tamil starring Ajith, titled Billa (2007).
* In 1986, the movie was remade in Malayalam as Sobharaj (1986), starring Mohanlal.
* The first Hindi remake was titled Dav Pech (1989), starring Jeetendra.
* A second Hindi remake made by Farhan Akhtar (son of Javed Akhtar who co-wrote the original film), (Don - The Chase Begins Again2006), stars Shahrukh Khan, Priyanka Chopra Isha Koppikar and Kareena Kapoor.
* Don is said to some of the elements of Shakti Samanta's film China Town (film) (1962), which had Shammi Kapoor playing a double role