It's 1971: Elmo McElroy (Samuel L. Jackson), fresh from graduating college with a degree in pharmacology, is pulled over by a patrol car and caught smoking marijuana. The police officer arrests him, thus preventing him from getting a legitimate job. Fast forward to the present day: a drug lord called the Lizard (Meat Loaf) calls a meeting with his organisation - hoping to sell a brand new substance. The deal goes awry when McElroy, in a bid to escape from the Lizard's control, blows up the building. Most inside are killed, but the Lizard manages to escape. Revenge very much on his mind, he contacts Dakota (Emily Mortimer), a contract killer, to take care of McElroy.